HitPredict

Interactor 1: ERR1 (P11474)
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
Gene: ESRRA

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	21988832
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 448
+	Hs
		369067 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		AKT2_HUMAN (111-442): 5.15e-125: 373: 20.86
+	Hs
		166529 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		DCLK1_HUMAN (25-447): 4.76e-120: 368: 18.42
+	Hs
		369066 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		160318 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12
+	Hs
		487911 RARA_HUMAN (8-419): 7.07e-111: 335: 25.24		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		369024 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49
+	Hs
		369888 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59
+	Hs
		622765 COT2_HUMAN (11-418): 1.31e-108: 327: 28.29		AKT2_HUMAN (111-442): 5.15e-125: 373: 20.86
+	Hs
		622764 COT2_HUMAN (11-418): 1.31e-108: 327: 28.29		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		377129 GCR_HUMAN (3-418): 4.49e-103: 324: 28.20		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		611379 NR4A1_HUMAN (3-422): 2.87e-104: 322: 29.95		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		1183083 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59
+	Hs
		647937 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49
+	Hs
		369519 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Mm
		103562 ESR1_MOUSE (5-420): 8.56e-110: 337: 33.63		G5E884_MOUSE (94-420): 6.57e-104: 321: 28.11
+	Hs
		611427 NR4A1_HUMAN (3-422): 2.87e-104: 322: 29.95		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		611430 NR4A1_HUMAN (3-422): 2.87e-104: 322: 29.95		STK3_HUMAN (138-421): 1.6e-106: 326: 32.53
+	Hs
		1269807 ESR2_HUMAN (4-420): 1.27e-100: 311: 33.11		STK26_HUMAN (155-421): 7.86e-106: 321: 35.66
+	Hs
		377146 GCR_HUMAN (3-418): 4.49e-103: 324: 28.20		MP2K2_HUMAN (146-448): 4.5e-81: 257: 40.06
+	Rn
		415134 GCR_RAT (75-337): 6.84e-43: 162: 36.53		MP2K2_RAT (146-448): 4.13e-83: 263: 40.63