HitPredict

Interactor 1: ERR1 (P11474)
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
Gene: ESRRA

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.833

Property	Details
Experiments	15604093, 23975195, 15337744
Identification Methods	two hybrid, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 1441
+	Hs
		587177 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		914651 ERR3_HUMAN (25-422): 2.3e-119: 357: 59.30		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		795598 NR4A2_HUMAN (18-418): 1.32e-116: 354: 28.17		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		659718 RXRB_HUMAN (20-420): 8.27e-116: 350: 28.86		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		500364 RARB_HUMAN (8-419): 2.41e-114: 344: 25.00		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		510022 ERR1_HUMAN (1-423): 2.92e-130: 383: 100.00		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Hs
		126103 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Hs
		914652 ERR3_HUMAN (25-422): 2.3e-119: 357: 59.30		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Hs
		320210 ERR2_HUMAN (3-422): 1.9e-116: 348: 56.10		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Mm
		914681 ERR3_MOUSE (25-422): 2.3e-119: 357: 59.30		EPAS1_MOUSE (15-890): 5.04e-96: 332: 13.94
+	Mm
		864788 ERR3_MOUSE (25-422): 2.3e-119: 357: 59.30		ARNT_MOUSE (4-656): 1.65e-93: 322: 16.20
+	Hs
		510047 ERR1_HUMAN (1-423): 2.92e-130: 383: 100.00		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		587212 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		181498 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Hs
		320237 ERR2_HUMAN (3-422): 1.9e-116: 348: 56.10		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		500381 RARB_HUMAN (8-419): 2.41e-114: 344: 25.00		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		510020 ERR1_HUMAN (1-423): 2.92e-130: 383: 100.00		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587173 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587195 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NPAS2_HUMAN (29-210): 2.08e-09: 64.3: 29.73
+	Hs
		320207 ERR2_HUMAN (3-422): 1.9e-116: 348: 56.10		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43