HitPredict

Interactor 1: ERR1 (P11474)
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
Gene: ESRRA

Interactor 2: NSD1 (Q96L73)
Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)
Gene: NSD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	23975195
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006355 - regulation of DNA-templated transcription GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 2696
+	Hs
		587193 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		370224 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Hs
		490110 COT1_HUMAN (30-418): 1.09e-111: 336: 29.67		NSD1_HUMAN (1-2696): 0: 3408: 100.00
+	Mm
		93747 RXRA_MOUSE (1-420): 3.07e-126: 374: 28.64		E9QAE4_MOUSE (1-2696): 0: 3312: 83.71
+	Hs
		203613 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		SUV91_HUMAN (1705-2081): 6.86e-87: 293: 21.86
+	Hs
		331692 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		NSD2_HUMAN (162-430): 3.61e-72: 270: 24.63
+	Hs
		370465 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		EHMT1_HUMAN (1781-2098): 2.45e-65: 247: 20.29
+	Hs
		370370 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		SETD2_HUMAN (1790-2119): 9.55e-63: 241: 27.98
+	Mm
		1125427 ERR2_MOUSE (3-422): 1.83e-112: 338: 54.46		EHMT1_MOUSE (1781-2098): 1.2e-64: 245: 20.00
+	Hs
		370223 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		EHMT2_HUMAN (1826-2080): 8.77e-63: 239: 22.49
+	Mm
		93590 ERR2_MOUSE (3-422): 1.83e-112: 338: 54.46		SETD2_MOUSE (1790-2119): 3.77e-62: 239: 27.68
+	Mm
		1142741 ERR2_MOUSE (3-422): 1.83e-112: 338: 54.46		EHMT2_MOUSE (1826-2080): 8.84e-62: 236: 22.49
+	Hs
		370371 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		NSD3_HUMAN (130-430): 6.42e-60: 231: 24.92
+	Hs
		500366 RARB_HUMAN (8-419): 2.41e-114: 344: 25.00		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		369688 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		EZH2_HUMAN (1883-2067): 7.8e-59: 220: 29.80
+	Hs
		370040 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		KMT2C_HUMAN (2086-2261): 7.67e-10: 67.3: 13.44
+	Hs
		152573 ESR1_HUMAN (5-420): 3.68e-112: 343: 33.86		KMT2D_HUMAN (1011-1538): 2.41e-09: 65.8: 8.69
+	Mm
		1142660 ERR2_MOUSE (3-422): 1.83e-112: 338: 54.46		KMT2D_MOUSE (1126-1530): 1.59e-10: 69.6: 12.75
+	Mm
		101828 ERR2_MOUSE (3-422): 1.83e-112: 338: 54.46		F8WI37_MOUSE (2088-2261): 1.86e-09: 66.2: 13.59
+	Mm
		1142676 ERR2_MOUSE (3-422): 1.83e-112: 338: 54.46		KMT2C_MOUSE (2088-2261): 1.86e-09: 66.2: 13.59