HitPredict

Interactor 1: ERR1 (P11474)
Steroid hormone receptor ERR1 (Estrogen receptor-like 1) (Estrogen-related receptor alpha) (ERR-alpha) (Nuclear receptor subfamily 3 group B member 1)
Gene: ESRRA

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	33450359, 10598588, 19462000, 15604093
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 1424
+	Hs
		587212 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		320237 ERR2_HUMAN (3-422): 1.9e-116: 348: 56.10		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		500381 RARB_HUMAN (8-419): 2.41e-114: 344: 25.00		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		510022 ERR1_HUMAN (1-423): 2.92e-130: 383: 100.00		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		587195 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		914652 ERR3_HUMAN (25-422): 2.3e-119: 357: 59.30		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		510020 ERR1_HUMAN (1-423): 2.92e-130: 383: 100.00		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		320210 ERR2_HUMAN (3-422): 1.9e-116: 348: 56.10		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		587173 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126103 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		320207 ERR2_HUMAN (3-422): 1.9e-116: 348: 56.10		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Mm
		914681 ERR3_MOUSE (25-422): 2.3e-119: 357: 59.30		EPAS1_MOUSE (12-872): 5.54e-91: 317: 13.77
+	Hs
		510021 ERR1_HUMAN (1-423): 2.92e-130: 383: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		181498 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		587177 RXRA_HUMAN (1-420): 2.08e-125: 372: 29.37		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		914651 ERR3_HUMAN (25-422): 2.3e-119: 357: 59.30		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		795598 NR4A2_HUMAN (18-418): 1.32e-116: 354: 28.17		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		659718 RXRB_HUMAN (20-420): 8.27e-116: 350: 28.86		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		500364 RARB_HUMAN (8-419): 2.41e-114: 344: 25.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Mm
		864788 ERR3_MOUSE (25-422): 2.3e-119: 357: 59.30		ARNT_MOUSE (6-673): 3.97e-70: 254: 16.23