HitPredict

Interactor 1: SSB1 (P11484)
Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)
Gene: SSB1

Interactor 2: SIS1 (P25294)
Protein SIS1
Gene: SIS1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	19536198, 33326013, 37845327
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 613 Sc			1 352
+	Sc
		510401 SSB1_YEAST (1-613): 0: 1128: 100.00		MAS5_YEAST (1-352): 1.41e-111: 332: 28.13
+	Sc
		633263 SSB2_YEAST (1-613): 0: 1118: 99.35		MAS5_YEAST (1-352): 1.41e-111: 332: 28.13
+	Sc
		628117 SSB2_YEAST (1-613): 0: 1118: 99.35		SIS1_YEAST (1-352): 6.96e-105: 313: 100.00
+	Hs
		564015 HSP76_HUMAN (3-612): 0: 901: 58.66		DNJA1_HUMAN (1-352): 2.53e-121: 357: 28.93
+	Hs
		243284 HSP76_HUMAN (3-612): 0: 901: 58.66		DNJA2_HUMAN (2-352): 5.07e-121: 356: 28.09
+	Hs
		503527 HSP7C_HUMAN (5-612): 0: 900: 59.84		DNJA1_HUMAN (1-352): 2.53e-121: 357: 28.93
+	Hs
		243275 HSP7C_HUMAN (5-612): 0: 900: 59.84		DNJA2_HUMAN (2-352): 5.07e-121: 356: 28.09
+	Hs
		483775 HS71B_HUMAN (5-611): 0: 897: 59.93		DNJA1_HUMAN (1-352): 2.53e-121: 357: 28.93
+	Hs
		243312 HS71L_HUMAN (5-612): 0: 896: 59.34		DNJA2_HUMAN (2-352): 5.07e-121: 356: 28.09
+	Hs
		564136 HSP76_HUMAN (3-612): 0: 901: 58.66		DNJA4_HUMAN (1-352): 3.62e-119: 351: 28.65
+	Hs
		279274 HSP76_HUMAN (3-612): 0: 901: 58.66		DNJB5_HUMAN (5-352): 6.21e-116: 341: 33.52
+	Hs
		279272 HSP7C_HUMAN (5-612): 0: 900: 59.84		DNJB5_HUMAN (5-352): 6.21e-116: 341: 33.52
+	Hs
		279280 HS71L_HUMAN (5-612): 0: 896: 59.34		DNJB5_HUMAN (5-352): 6.21e-116: 341: 33.52
+	Hs
		564203 HSP76_HUMAN (3-612): 0: 901: 58.66		DNJB4_HUMAN (5-352): 1.08e-112: 332: 34.08
+	Hs
		504901 HSP7C_HUMAN (5-612): 0: 900: 59.84		DNJB4_HUMAN (5-352): 1.08e-112: 332: 34.08
+	Hs
		483809 HS71B_HUMAN (5-611): 0: 897: 59.93		DNJB4_HUMAN (5-352): 1.08e-112: 332: 34.08
+	Hs
		564008 HSP76_HUMAN (3-612): 0: 901: 58.66		DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09
+	Hs
		503463 HSP7C_HUMAN (5-612): 0: 900: 59.84		DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09
+	Hs
		483773 HS71B_HUMAN (5-611): 0: 897: 59.93		DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09
+	Hs
		636256 HS71L_HUMAN (5-612): 0: 896: 59.34		DNJB1_HUMAN (5-352): 5.62e-109: 323: 34.09