HitPredict

Interactor 1: SSB1 (P11484)
Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)
Gene: SSB1

Interactor 2: LHS1 (P36016)
Heat shock protein 70 homolog LHS1 (EC 3.6.1.-)
Gene: LHS1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP70~HSP70
Common GO terms	GO:0005524 - ATP binding GO:0016887 - ATP hydrolysis activity GO:0051082 - unfolded protein binding GO:0140662 - ATP-dependent protein folding chaperone
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 613 Sc			1 881
+	Hs
		503543 HSP7C_HUMAN (5-612): 0: 900: 59.84		HS71L_HUMAN (18-688): 0: 821: 19.73
+	Hs
		503389 HSP76_HUMAN (3-612): 0: 901: 58.66		HSP7C_HUMAN (18-682): 0: 802: 19.61
+	Hs
		503315 HSP7C_HUMAN (5-612): 0: 900: 59.84		HSP7C_HUMAN (18-682): 0: 802: 19.61
+	Mm
		926115 HSP7C_MOUSE (5-612): 0: 900: 59.84		HSP7C_MOUSE (18-682): 0: 802: 19.61
+	Mm
		571859 HS71A_MOUSE (5-611): 0: 893: 59.44		HS71B_MOUSE (18-680): 0: 802: 19.97
+	Hs
		564046 HSP76_HUMAN (3-612): 0: 901: 58.66		HSP72_HUMAN (16-681): 0: 793: 19.28
+	Hs
		503752 HSP7C_HUMAN (5-612): 0: 900: 59.84		HSP72_HUMAN (16-681): 0: 793: 19.28
+	Hs
		871593 Q53FC7_HUMAN (3-612): 0: 897: 58.33		HSP72_HUMAN (16-681): 0: 793: 19.28
+	Sc
		510278 SSB1_YEAST (1-613): 0: 1128: 100.00		HSP74_YEAST (76-668): 1.86e-31: 133: 23.32
+	Sc
		490139 SSB1_YEAST (1-613): 0: 1128: 100.00		HSP71_YEAST (76-574): 4.96e-31: 132: 24.55
+	Sc
		449874 SSB1_YEAST (1-613): 0: 1128: 100.00		HSP73_YEAST (76-668): 9.25e-31: 131: 23.71
+	Sc
		493029 SSB1_YEAST (1-613): 0: 1128: 100.00		HSP72_YEAST (76-574): 1.07e-30: 130: 24.45
+	Sc
		491383 SSB2_YEAST (1-613): 0: 1118: 99.35		HSP71_YEAST (76-574): 4.96e-31: 132: 24.55
+	Sc
		450060 SSB2_YEAST (1-613): 0: 1118: 99.35		HSP73_YEAST (76-668): 9.25e-31: 131: 23.71
+	Sc
		494100 SSB2_YEAST (1-613): 0: 1118: 99.35		HSP72_YEAST (76-574): 1.07e-30: 130: 24.45
+	Hs
		505010 HSP7C_HUMAN (5-612): 0: 900: 59.84		HYOU1_HUMAN (21-481): 2.67e-52: 200: 29.83