HitPredict

Interactor 1: HS90B (P11499)
Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) (Tumor-specific transplantation 84 kDa antigen) (TSTA)
Gene: Hsp90ab1

Interactor 2: CDKL5 (Q3UTQ8)
Cyclin-dependent kinase-like 5 (EC 2.7.11.22)
Gene: CDKL5

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36417873
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0044294 - dendritic growth cone GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 938
+	Hs
		437908 HS90B_HUMAN (1-724): 0: 1079: 99.59		CDK2_HUMAN (10-303): 1.85e-150: 447: 37.16
+	Hs
		431549 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDK2_HUMAN (10-303): 1.85e-150: 447: 37.16
+	Hs
		438075 HS90B_HUMAN (1-724): 0: 1079: 99.59		CDK3_HUMAN (10-299): 1.17e-142: 428: 37.67
+	Hs
		431741 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDK3_HUMAN (10-299): 1.17e-142: 428: 37.67
+	Hs
		438077 HS90B_HUMAN (1-724): 0: 1079: 99.59		CDK5_HUMAN (10-303): 3.06e-134: 405: 39.19
+	Hs
		414683 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDK1_HUMAN (10-302): 2.96e-136: 411: 37.84
+	Hs
		431743 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDK5_HUMAN (10-303): 3.06e-134: 405: 39.19
+	Hs
		432124 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDKL2_HUMAN (10-461): 4.17e-131: 405: 36.42
+	Hs
		438250 HS90B_HUMAN (1-724): 0: 1079: 99.59		CDKL4_HUMAN (10-299): 2.03e-85: 280: 46.74
+	Hs
		538107 ENPL_HUMAN (3-696): 0: 912: 46.38		CDK2_HUMAN (10-303): 1.85e-150: 447: 37.16
+	Hs
		431937 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDKL4_HUMAN (10-299): 2.03e-85: 280: 46.74
+	Ca
		793050 HSP90_CANAL (8-724): 0: 928: 60.56		CDK1_CANAL (10-297): 2.21e-131: 399: 38.23
+	Sc
		543134 HSC82_YEAST (13-724): 0: 919: 60.36		FUS3_YEAST (1-316): 1.08e-126: 388: 32.93
+	Hs
		438342 HS90B_HUMAN (1-724): 0: 1079: 99.59		CDK20_HUMAN (10-302): 1.41e-56: 200: 40.00
+	Hs
		438004 HS90B_HUMAN (1-724): 0: 1079: 99.59		CDK7_HUMAN (12-300): 8.5e-54: 192: 38.10
+	Hs
		432045 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDK20_HUMAN (10-302): 1.41e-56: 200: 40.00
+	Hs
		431662 HS90A_HUMAN (1-724): 0: 1066: 85.66		CDK7_HUMAN (12-300): 8.5e-54: 192: 38.10
+	Sc
		339312 HSP82_YEAST (12-724): 0: 924: 61.40		CDK1_YEAST (10-298): 4.23e-53: 189: 39.20
+	Sp
		383458 HSP90_SCHPO (10-724): 0: 926: 62.76		CDK1_SCHPO (10-235): 1.54e-52: 187: 42.98
+	Sc
		339406 HSC82_YEAST (13-724): 0: 919: 60.36		CDK1_YEAST (10-298): 4.23e-53: 189: 39.20