HitPredict

Interactor 1: PDIA3 (P11598)
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60) (HIP-70) (Q-2)
Gene: PDIA3

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001666 - response to hypoxia GO:0031667 - response to nutrient levels GO:0045471 - response to ethanol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Rn			1 1383
+	Hs
		411271 PDIA1_HUMAN (17-482): 1.37e-122: 370: 32.77		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Rn
		544870 PDIA6_RAT (356-478): 1.01e-24: 108: 26.61		INSR_RAT (1-1383): 0: 1575: 100.00
+	Hs
		423108 PDIA1_HUMAN (17-482): 1.37e-122: 370: 32.77		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		411430 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		435692 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		537757 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		INSRR_HUMAN (12-1339): 0: 1276: 51.80
+	Hs
		384339 PDIA3_HUMAN (1-505): 4.67e-161: 468: 92.28		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		1072583 ERP44_HUMAN (369-500): 4.11e-25: 109: 19.71		EPHA7_HUMAN (664-1321): 0: 568: 22.55
+	Hs
		384104 PDIA1_HUMAN (17-482): 1.37e-122: 370: 32.77		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		337993 PDIA3_HUMAN (1-505): 4.67e-161: 468: 92.28		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		337778 PDIA1_HUMAN (17-482): 1.37e-122: 370: 32.77		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		445858 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		ROS1_HUMAN (1020-1292): 1.06e-71: 267: 49.46
+	Hs
		385136 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		169199 ERP44_HUMAN (369-500): 4.11e-25: 109: 19.71		MUSK_HUMAN (1018-1292): 3.32e-69: 253: 42.22
+	Hs
		1081525 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		385355 TMX3_HUMAN (375-482): 3.39e-27: 116: 36.36		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		385431 ERP44_HUMAN (369-500): 4.11e-25: 109: 19.71		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		1081585 ERP44_HUMAN (369-500): 4.11e-25: 109: 19.71		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		338668 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383876 DJC10_HUMAN (26-243): 8.7e-31: 128: 18.78		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83