HitPredict

Interactor 1: RYR1 (P11716)
Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
Gene: RYR1

Interactor 2: RYR1 (P11716)
Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
Gene: RYR1

Species: Oryctolagus cuniculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.911

The method score is based on:

Property Details
Experiments 17361990, 14722100, 2550460, 16084392, 25470059
Identification Methods pull down, unspecified method, cosedimentation in solution, 3D electron microscopy, electron microscopy, cross-linking study
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ins145_P3_rec~Ins145_P3_rec, Ins145_P3_rec~MIR, Ins145_P3_rec~RIH_assoc, Ins145_P3_rec~RYDR_ITPR, Ion_trans~Ion_trans, Ion_trans~RR_TM4-6, MIR~MIR, MIR~RYDR_ITPR, RR_TM4-6~RR_TM4-6, RYDR_ITPR~RYDR_ITPR, RYDR_ITPR~SPRY, RyR~RyR, RyR~SPRY, SPRY~SPRY
Common GO terms GO:0003151 - outflow tract morphogenesis
GO:0005219 - ryanodine-sensitive calcium-release channel activity
GO:0005245 - voltage-gated calcium channel activity
GO:0005262 - calcium channel activity
GO:0005509 - calcium ion binding
and 28 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 5037
Oc

1 5037
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Rn
+ Hs
+ Ce
+ Hs
+ Dm
+ Hs
+ Dm

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Last updated: 15 Jul 2024