HitPredict

Interactor 1: MPRI (P11717)
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Gene: IGF2R

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0010008 - endosome membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2491 Hs			1 258
+	Hs
		436138 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOC_HUMAN (51-231): 3.2e-89: 264: 46.96
+	Hs
		514799 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		514816 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		514810 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		514808 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		514804 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		514754 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		514800 MPRI_HUMAN (1-2491): 0: 4161: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		514758 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		514906 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Hs
		925694 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		914427 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		901008 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545677 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		363046 FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		363025 FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87