HitPredict

Interactor 1: MPRI (P11717)
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Gene: IGF2R

Interactor 2: RHOF (Q9HBH0)
Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia)
Gene: RHOF

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030667 - secretory granule membrane GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 2491 Hs			1 211
+	Hs
		120290 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOD_HUMAN (5-198): 4.14e-90: 265: 52.06
+	Hs
		514810 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RAC1_HUMAN (20-211): 9.06e-84: 248: 49.48
+	Hs
		514754 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RAC2_HUMAN (20-211): 2.82e-79: 237: 49.48
+	Hs
		514816 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOG_HUMAN (19-211): 4.47e-79: 236: 46.11
+	Hs
		514804 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOA_HUMAN (21-211): 1.51e-78: 235: 48.69
+	Hs
		514758 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOQ_HUMAN (14-209): 4.28e-77: 232: 46.43
+	Hs
		514799 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RAC3_HUMAN (20-193): 1.33e-77: 232: 50.58
+	Hs
		514800 MPRI_HUMAN (1-2491): 0: 4161: 100.00		CDC42_HUMAN (19-211): 1.19e-77: 232: 44.04
+	Hs
		436138 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOC_HUMAN (21-211): 1.44e-76: 230: 49.22
+	Hs
		514809 MPRI_HUMAN (1-2491): 0: 4161: 100.00		RHOB_HUMAN (21-200): 2.02e-58: 184: 48.89
+	Hs
		925694 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RAC1_HUMAN (20-211): 9.06e-84: 248: 49.48
+	Hs
		545677 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RAC2_HUMAN (20-211): 2.82e-79: 237: 49.48
+	Hs
		901008 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RHOA_HUMAN (21-211): 1.51e-78: 235: 48.69
+	Hs
		363046 FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63		RAC1_HUMAN (20-211): 9.06e-84: 248: 49.48
+	Hs
		916042 MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23		RHOB_HUMAN (21-200): 2.02e-58: 184: 48.89