HitPredict

Interactor 1: MPRI (P11717)
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Gene: IGF2R

Interactor 2: GGA3 (Q9NZ52)
ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Gene: GGA3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

Property	Details
Experiments	11859375, 16135791, 12032548, 14567678, 12060753, 11390366, unassigned3413, 16977309, 11387475
Identification Methods	x-ray crystallography, two hybrid, affinity chromatography technology, fluorescence polarization spectroscopy, pull down
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005802 - trans-Golgi network GO:0010008 - endosome membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2491 Hs			1 723
+	Hs
		514929 MPRI_HUMAN (1-2491): 0: 4161: 100.00		GGA1_HUMAN (2-723): 1.09e-91: 301: 39.78
+	Bt
		59972 MPRI_BOVIN (1-2491): 0: 4005: 80.50		A4FUZ8_BOVIN (1-589): 9.76e-109: 343: 73.57
+	Mm
		612131 MPRI_MOUSE (7-2491): 0: 4155: 81.31		AP1G1_MOUSE (503-720): 3.11e-50: 190: 26.09
+	Bt
		436870 MPRI_BOVIN (1-2491): 0: 4005: 80.50		Q58CQ6_BOVIN (2-452): 5.4e-89: 287: 46.93
+	Hs
		514928 MPRI_HUMAN (1-2491): 0: 4161: 100.00		GGA2_HUMAN (456-721): 1.1e-25: 114: 34.83
+	Bt
		102288 MPRI_BOVIN (1-2491): 0: 4005: 80.50		G3MZH4_BOVIN (503-720): 4.8e-57: 209: 26.15
+	Dm
		81395 B7Z0Q8_DROME (917-1647): 2.46e-35: 149: 22.54		Q9W329_DROME (9-705): 8.66e-69: 240: 22.06