HitPredict

Interactor 1: KCC2A (P11798)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: Camk2a

Interactor 2: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	27507650, 28671696, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0043197 - dendritic spine GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 478 Mm			1 1730
+	Mm
		1115965 KCC2D_MOUSE (2-475): 0: 552: 87.55		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		1116071 KCC2G_MOUSE (1-475): 0: 525: 76.43		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Mm
		659451 KCC2B_MOUSE (1-475): 1.19e-178: 513: 71.06		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Rn
		506766 KCC2A_RAT (1-478): 0: 569: 100.00		CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84
+	Mm
		439494 KCC4_MOUSE (13-303): 3.74e-72: 237: 43.69		SHAN3_MOUSE (1-1730): 0: 626: 100.00
+	Hs
		1038922 KCC2B_HUMAN (218-475): 9.21e-59: 206: 42.44		SHAN3_HUMAN (1-1730): 0: 601: 95.21
+	Rn
		1144073 CSKP_RAT (9-307): 2.45e-85: 282: 46.08		CSKI1_RAT (55-1403): 1.26e-108: 382: 15.84
+	Hs
		1083221 KCC4_HUMAN (9-303): 2.31e-73: 240: 43.10		ANR52_HUMAN (14-494): 3.38e-78: 284: 16.60
+	Hs
		166938 KCC4_HUMAN (9-303): 2.31e-73: 240: 43.10		ANR28_HUMAN (224-592): 3.91e-43: 174: 14.60
+	Hs
		159247 CSKP_HUMAN (9-307): 2.56e-85: 283: 46.08		CSKI1_HUMAN (954-1663): 8.42e-09: 62.8: 13.73