HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: RFA2 (P15927)
Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34)
Gene: RPA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20679368, 37827155
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 270
+	Hs
		551975 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00
+	Hs
		414714 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00
+	Hs
		552507 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00
+	Hs
		552508 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		RFA2_HUMAN (1-270): 1.68e-127: 364: 100.00
+	Hs
		414898 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		RFA4_HUMAN (1-268): 6.87e-96: 283: 45.56
+	Ca
		793056 CDK1_CANAL (1-295): 1.13e-124: 360: 44.19		Q59Z33_CANAL (4-264): 1.49e-64: 204: 26.37