HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: H13 (P16402)
Histone H1.3 (Histone H1c) (Histone H1s-2)
Gene: H1-3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18850315
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 221
+	Rn
		413197 Q6P751_RAT (3-301): 1.66e-144: 410: 43.89		H1T_RAT (1-219): 3.85e-36: 127: 49.32
+	Hs
		559328 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		H13_HUMAN (1-182): 1.29e-30: 114: 100.00
+	Rn
		88903 Q6P751_RAT (3-301): 1.66e-144: 410: 43.89		H11_RAT (1-121): 6.42e-22: 91.3: 68.85
+	Hs
		558990 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		H15_HUMAN (1-116): 3.39e-20: 87.1: 82.20
+	Hs
		625377 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81
+	Hs
		414717 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		H13_HUMAN (1-182): 1.29e-30: 114: 100.00
+	Mm
		794656 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		H15_MOUSE (1-204): 3.87e-22: 92.1: 70.59
+	Mm
		550489 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		H12_MOUSE (33-116): 1.07e-16: 77.4: 97.62
+	Mm
		794643 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		H11_MOUSE (1-122): 1.46e-16: 77: 69.11
+	Rn
		88899 CDK1_RAT (3-300): 1e-129: 372: 42.24		H11_RAT (1-121): 6.42e-22: 91.3: 68.85
+	Hs
		414716 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		H15_HUMAN (1-116): 3.39e-20: 87.1: 82.20
+	Mm
		673226 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		H15_MOUSE (1-204): 3.87e-22: 92.1: 70.59
+	Hs
		414874 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81
+	Hs
		515403 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81
+	Mm
		509461 CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24		H12_MOUSE (33-116): 1.07e-16: 77.4: 97.62
+	Hs
		960154 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		H11_HUMAN (39-182): 9.17e-18: 80.1: 61.81
+	Mm
		509472 CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24		H11_MOUSE (1-122): 1.46e-16: 77: 69.11
+	Mm
		794650 CDK6_MOUSE (5-300): 2.33e-127: 367: 69.70		H11_MOUSE (1-122): 1.46e-16: 77: 69.11
+	Mm
		550487 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		H12_MOUSE (33-116): 1.07e-16: 77.4: 97.62
+	Mm
		673225 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		H11_MOUSE (1-122): 1.46e-16: 77: 69.11