HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase, Pkinase~SAM_1
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 976
+	Hs
		665211 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		411301 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		INSR_HUMAN (281-933): 1.71e-136: 445: 24.85
+	Hs
		609180 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		435611 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		414687 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		435516 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		414738 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		433583 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		414685 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433544 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91