HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 23007395, 28514442, 23737759, 15695403, 17556661, 18850315, 9658399, 9632134, 9464540, 8756624, 15232106, 11463845, 10022865, 30833792, 33961781, 20102411, 15169570, 12383116, 8622677, 23443559 and 4 others

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Identification Methods affinity chromatography technology, enzymatic study, pull down, two hybrid, protein array, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CDI~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 303
Hs

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Last updated: 15 Jul 2024