HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: BAG6 (P46379)
Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)
Gene: BAG6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	16169070, 17353931
Identification Methods	two hybrid, anti bait coimmunoprecipitation, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 1132
+	Hs
		803487 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		BAG6_HUMAN (1-1132): 0: 597: 100.00
+	Hs
		625332 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		RS27A_HUMAN (17-87): 2.18e-27: 111: 34.72
+	Hs
		415095 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		UBQL2_HUMAN (13-587): 2.27e-26: 117: 14.71
+	Hs
		515526 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		UBQL2_HUMAN (13-587): 2.27e-26: 117: 14.71
+	Hs
		625532 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CBP_HUMAN (204-749): 1.19e-09: 65.1: 12.25
+	Sc
		339331 CDK1_YEAST (4-297): 5.64e-119: 345: 42.38		RS31_YEAST (17-85): 3.43e-11: 64.4: 34.29
+	Sc
		565688 PHO85_YEAST (2-295): 1.8e-68: 217: 41.10		DSK2_YEAST (16-332): 1.34e-26: 115: 20.06
+	Sc
		477595 PHO85_YEAST (2-295): 1.8e-68: 217: 41.10		RL40A_YEAST (17-87): 6.63e-27: 108: 34.72