HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CEBPA (P49715)
CCAAT/enhancer-binding protein alpha (C/EBP alpha)
Gene: CEBPA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15107404, 11684017
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005730 - nucleolus and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 358
+	Hs
		625234 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CEBPA_HUMAN (1-358): 1.35e-69: 223: 100.00
+	Mm
		862806 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		CEBPA_MOUSE (1-358): 4.3e-64: 209: 91.19
+	Hs
		414821 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CEBPA_HUMAN (1-358): 1.35e-69: 223: 100.00
+	Mm
		509477 CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24		CEBPA_MOUSE (1-358): 4.3e-64: 209: 91.19
+	Mm
		673229 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		CEBPA_MOUSE (1-358): 4.3e-64: 209: 91.19
+	Hs
		625260 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CEBPG_HUMAN (225-347): 4.57e-24: 98.3: 30.89