HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDN1C (P49918)
Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
Gene: CDKN1C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	10713702, 33961781, 9106657
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CDI~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 316
+	Hs
		625237 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		836898 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Hs
		625186 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Rn
		139842 CDK2_RAT (3-301): 5.1e-145: 411: 44.22		O08769_RAT (9-201): 8.07e-25: 100: 24.35
+	Hs
		625207 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		758188 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Mm
		763415 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		414825 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CDN1C_HUMAN (1-316): 3.21e-37: 137: 100.00
+	Mm
		803840 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		CDN1B_MOUSE (9-201): 1.47e-28: 110: 23.83
+	Hs
		804104 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Mm
		509470 CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24		CDN1A_MOUSE (16-155): 5.85e-33: 121: 27.78
+	Hs
		414796 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Xl
		1153623 Q6IRQ7_XENLA (3-302): 2.31e-142: 404: 42.76		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Xl
		616668 CDK2_XENLA (3-302): 4.6e-142: 403: 43.09		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46
+	Hs
		515361 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CDN1A_HUMAN (17-148): 7.59e-31: 115: 29.20
+	Hs
		625528 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		TITIN_HUMAN (92-310): 7.91e-10: 62.3: 9.77
+	Hs
		414811 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		515368 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		CDN1B_HUMAN (9-201): 9.76e-25: 100: 21.76
+	Hs
		515493 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		Q96TE0_HUMAN (9-201): 1.11e-24: 100: 21.76
+	Xl
		724512 CDK1A_XENLA (3-302): 1.37e-129: 372: 41.64		Q91646_XENLA (26-155): 1.89e-17: 81.3: 28.46