HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.866

The method score is based on:

Property Details
Experiments 28205554, 33961781, 23455922
Identification Methods fluorescent resonance energy transfer, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 12 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 303
Hs

1 326
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Last updated: 15 Jul 2024