HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: H11 (Q02539)
Histone H1.1 (Histone H1a)
Gene: H1-1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	16878158, 16431923, 11132966, 10447003, 9464540
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 215
+	Rn
		413197 Q6P751_RAT (3-301): 1.66e-144: 410: 43.89		H1T_RAT (1-213): 4.75e-37: 130: 48.37
+	Hs
		559328 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Rn
		88903 Q6P751_RAT (3-301): 1.66e-144: 410: 43.89		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		558990 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		625377 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Mm
		794656 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		H15_MOUSE (1-199): 6.17e-23: 94: 56.59
+	Hs
		414717 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Hs
		515324 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		H13_HUMAN (1-169): 5.79e-27: 104: 55.03
+	Mm
		550489 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		794643 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Rn
		88899 CDK1_RAT (3-300): 1e-129: 372: 42.24		H11_RAT (1-123): 9.41e-24: 95.9: 77.24
+	Hs
		414716 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		H15_HUMAN (1-118): 1.18e-22: 93.2: 72.88
+	Hs
		414874 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Mm
		673226 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		H15_MOUSE (1-199): 6.17e-23: 94: 56.59
+	Hs
		960154 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		H11_HUMAN (1-199): 7.29e-21: 88.2: 100.00
+	Mm
		509461 CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		509472 CDK1_MOUSE (3-300): 1.06e-128: 370: 42.24		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Mm
		794650 CDK6_MOUSE (5-300): 2.33e-127: 367: 69.70		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84
+	Mm
		550487 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		H12_MOUSE (33-118): 1.42e-17: 79.4: 80.23
+	Mm
		673225 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		H11_MOUSE (1-124): 1.61e-17: 79.4: 79.84