HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29845934
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 582
+	Hs
		625477 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		960098 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		414946 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		960190 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		960291 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		403088 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		516362 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	At
		1103363 CKB12_ARATH (3-300): 6.13e-125: 360: 39.62		LRP1A_ARATH (10-367): 4.77e-56: 204: 16.85
+	Sc
		339316 CDK1_YEAST (4-297): 5.64e-119: 345: 42.38		PABP_YEAST (9-243): 8.44e-33: 134: 13.47
+	Hs
		414931 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Sc
		565522 PHO85_YEAST (2-295): 1.8e-68: 217: 41.10		LHP1_YEAST (7-270): 1.34e-45: 163: 22.74
+	Dm
		582590 CDK2_DROME (6-295): 8.61e-69: 218: 43.88		SXL_DROME (59-259): 1.13e-24: 107: 20.29