HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051726 - regulation of cell cycle
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 1164
+	Hs
		415012 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		960223 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Mm
		829610 CDK5_MOUSE (3-301): 6.95e-124: 357: 43.09		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		625530 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		625176 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MYH9_HUMAN (673-1164): 1.25e-23: 111: 12.40
+	Hs
		551610 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		522542 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH1_HUMAN (393-967): 5.76e-21: 102: 11.23
+	Hs
		528368 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH6_HUMAN (623-1102): 9.65e-21: 101: 14.55
+	Hs
		960128 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH2_HUMAN (393-980): 6.89e-21: 101: 11.32
+	Hs
		522604 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH7_HUMAN (391-922): 3.39e-17: 89.9: 8.59
+	Hs
		148286 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		528401 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MYH8_HUMAN (822-1163): 6.53e-11: 69.1: 10.73
+	Hs
		414713 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		DESP_HUMAN (570-1151): 1.05e-21: 104: 11.54
+	Hs
		625177 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MYH10_HUMAN (687-992): 3.26e-09: 63.6: 20.43
+	Hs
		528405 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH8_HUMAN (822-1163): 6.53e-11: 69.1: 10.73
+	Hs
		502908 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH3_HUMAN (400-850): 1.77e-10: 67.9: 10.00
+	Hs
		960129 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH13_HUMAN (628-994): 2.22e-10: 67.5: 20.45