HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CHIP (Q9UNE7)
E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Antigen NY-CO-7) (CLL-associated antigen KW-8) (Carboxy terminus of Hsp70-interacting protein) (RING-type E3 ubiquitin transferase CHIP) (STIP1 homology and U box-containing protein 1)
Gene: STUB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	29326975
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 303
+	Hs
		1154347 Q6LC83_HUMAN (75-303): 7.08e-125: 357: 100.00		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Hs
		960345 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		CHIP_HUMAN (1-303): 3.8e-69: 218: 100.00
+	Mm
		829611 CDK5_MOUSE (3-301): 6.95e-124: 357: 43.09		CHIP_MOUSE (1-303): 1.23e-67: 214: 97.37
+	At
		1106347 MPK4_ARATH (9-300): 1.19e-125: 365: 34.34		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	At
		1259046 MPK16_ARATH (4-302): 1.74e-122: 363: 32.69		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	Mm
		673236 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22
+	At
		1106458 MPK5_ARATH (3-302): 2.25e-122: 357: 36.25		PUB7_ARATH (45-298): 6.22e-31: 124: 15.73
+	Mm
		829607 CDK5_MOUSE (3-301): 6.95e-124: 357: 43.09		WDTC1_MOUSE (21-272): 7.36e-30: 120: 19.22