HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	30561431
Identification Methods	affinity chromatography technology, virotrap
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 419
+	Hs
		625664 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		625548 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		415018 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		OPTN_HUMAN (67-418): 2.78e-38: 147: 27.25
+	Hs
		625654 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MYO5A_HUMAN (38-342): 1.7e-24: 108: 14.65
+	Hs
		551610 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		415051 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		SCAPE_HUMAN (25-345): 4.15e-29: 122: 16.91
+	Hs
		625176 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MYH9_HUMAN (11-402): 4.5e-11: 67.3: 9.93
+	Hs
		625177 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MYH10_HUMAN (27-387): 1.16e-10: 65.8: 14.09
+	Hs
		528401 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MYH8_HUMAN (22-392): 1.71e-09: 62.3: 11.87
+	Hs
		625530 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		MY18A_HUMAN (10-390): 4.23e-09: 60.8: 15.89
+	Hs
		414713 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		522542 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH1_HUMAN (33-391): 2.48e-10: 65: 11.75
+	Hs
		522604 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH7_HUMAN (26-376): 1.58e-09: 62.3: 13.24
+	Hs
		528368 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH6_HUMAN (4-395): 1.4e-09: 62.3: 11.48
+	Hs
		528405 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH8_HUMAN (22-392): 1.71e-09: 62.3: 11.87
+	Hs
		960128 CDK3_HUMAN (3-302): 7.81e-139: 395: 44.74		MYH2_HUMAN (1-396): 8.43e-09: 60: 9.77