HitPredict

Interactor 1: ITB2 (P11835)
Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18)
Gene: Itgb2

Interactor 2: TLN1 (P26039)
Talin-1
Gene: TLN1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30333137
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005925 - focal adhesion GO:0007229 - integrin-mediated signaling pathway GO:0009986 - cell surface GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 771 Mm			1 2541
+	Hs
		404003 ITB1_HUMAN (8-768): 0: 681: 45.20		TLN1_HUMAN (1-2541): 0: 1492: 98.74
+	Mm
		447067 ITB1_MOUSE (9-768): 0: 680: 45.13		TLN1_MOUSE (1-2541): 0: 1492: 100.00
+	Hs
		396659 ITB2_HUMAN (1-771): 0: 718: 81.84		TLN2_HUMAN (1-2541): 0: 1448: 75.83
+	Rn
		102527 ITB1_RAT (9-768): 0: 677: 44.57		G3V852_RAT (1-2541): 0: 1487: 99.37
+	Mm
		222504 ITB3_MOUSE (22-768): 0: 616: 38.99		TLN1_MOUSE (1-2541): 0: 1492: 100.00
+	Hs
		574588 ITB5_HUMAN (24-762): 0: 607: 37.47		TLN2_HUMAN (1-2541): 0: 1448: 75.83
+	Hs
		403763 ITB1_HUMAN (8-768): 0: 681: 45.20		EZRI_HUMAN (84-650): 4.79e-86: 296: 14.41
+	Hs
		396615 ITB2_HUMAN (1-771): 0: 718: 81.84		RADI_HUMAN (163-404): 1.93e-57: 212: 22.27
+	Mm
		515645 ITB2_MOUSE (1-771): 0: 706: 100.00		RADI_MOUSE (163-404): 6.16e-57: 211: 22.27
+	Hs
		403804 ITB1_HUMAN (8-768): 0: 681: 45.20		RADI_HUMAN (163-404): 1.93e-57: 212: 22.27
+	Hs
		403915 ITB1_HUMAN (8-768): 0: 681: 45.20		URP2_HUMAN (200-416): 6.26e-52: 198: 23.74
+	Mm
		515690 ITB2_MOUSE (1-771): 0: 706: 100.00		PLEC_MOUSE (1236-2541): 2.97e-22: 108: 11.47
+	Mm
		447132 ITB1_MOUSE (9-768): 0: 680: 45.13		PLEC_MOUSE (1236-2541): 2.97e-22: 108: 11.47
+	Hs
		403934 ITB1_HUMAN (8-768): 0: 681: 45.20		FERM2_HUMAN (268-416): 1.72e-11: 72: 27.82
+	Mm
		447114 ITB1_MOUSE (9-768): 0: 680: 45.13		FERM2_MOUSE (268-416): 3.4e-11: 70.9: 28.48
+	Rn
		824605 ITB1_RAT (9-768): 0: 677: 44.57		Q5XI19_RAT (268-416): 3.34e-11: 70.9: 28.48
+	Hs
		403954 ITB1_HUMAN (8-768): 0: 681: 45.20		FERM1_HUMAN (268-422): 4.74e-09: 63.9: 24.20
+	Mm
		222586 ITB3_MOUSE (22-768): 0: 616: 38.99		PLEC_MOUSE (1236-2541): 2.97e-22: 108: 11.47
+	Mm
		250702 ITB5_MOUSE (9-762): 0: 607: 36.75		MYO7A_MOUSE (83-382): 6.15e-17: 90.3: 18.91
+	Hs
		574564 ITB5_HUMAN (24-762): 0: 607: 37.47		FERM2_HUMAN (268-416): 1.72e-11: 72: 27.82