HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: LAR4B (Q92615)
La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5)
Gene: LARP4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.853

Property	Details
Experiments	29395067, 33961781, 35044719
Identification Methods	proximity labelling technology, affinity chromatography technology, unspecified method, phage display, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	La~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 636 Hs			1 738
+	Hs
		1031407 PABP4_HUMAN (1-635): 0: 534: 74.69		LAR4B_HUMAN (1-738): 0: 654: 100.00
+	Hs
		516568 PABP1_HUMAN (1-636): 0: 582: 100.00		LARP4_HUMAN (50-738): 1.65e-168: 503: 36.78
+	Hs
		1268142 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		LAR4B_HUMAN (1-738): 0: 654: 100.00
+	Hs
		474033 PAB4L_HUMAN (187-380): 1.23e-36: 142: 29.74		LAR4B_HUMAN (1-738): 0: 654: 100.00
+	Hs
		516561 PABP1_HUMAN (1-636): 0: 582: 100.00		LARP1_HUMAN (31-367): 7.91e-52: 197: 16.19
+	Hs
		516541 PABP1_HUMAN (1-636): 0: 582: 100.00		LARP7_HUMAN (154-461): 2.7e-44: 170: 15.43
+	Hs
		1031367 PABP4_HUMAN (1-635): 0: 534: 74.69		LARP1_HUMAN (31-367): 7.91e-52: 197: 16.19
+	Hs
		403212 PABP4_HUMAN (1-635): 0: 534: 74.69		LA_HUMAN (156-519): 9.57e-49: 179: 10.15
+	Hs
		1116542 PABP3_HUMAN (1-636): 0: 541: 91.37		LARP7_HUMAN (154-461): 2.7e-44: 170: 15.43
+	Hs
		516553 PABP1_HUMAN (1-636): 0: 582: 100.00		LAR1B_HUMAN (114-266): 3.23e-28: 123: 16.99
+	Hs
		1031352 PABP4_HUMAN (1-635): 0: 534: 74.69		LARP7_HUMAN (154-461): 2.7e-44: 170: 15.43
+	Hs
		1116304 PAP1L_HUMAN (1-628): 9.51e-166: 489: 68.20		LARP7_HUMAN (154-461): 2.7e-44: 170: 15.43
+	Hs
		1174835 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		LARP4_HUMAN (50-738): 1.65e-168: 503: 36.78
+	At
		285478 PABP8_ARATH (2-482): 1.38e-62: 221: 24.10		LRP6B_ARATH (64-365): 2.42e-54: 197: 14.54
+	Sc
		376709 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		LHP1_YEAST (137-369): 5.71e-44: 161: 17.65
+	Dm
		597071 PABP_DROME (2-448): 6.58e-63: 221: 25.21		LARP_DROME (62-250): 4.89e-30: 129: 21.16
+	Hs
		1162644 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		LARP1_HUMAN (31-367): 7.91e-52: 197: 16.19
+	Sc
		376650 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		SRO9_YEAST (158-216): 8.85e-09: 60.3: 27.87
+	Hs
		403080 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		LA_HUMAN (156-519): 9.57e-49: 179: 10.15
+	Hs
		1145698 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		LAR1B_HUMAN (114-266): 3.23e-28: 123: 16.99