HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: M3K14 (Q99558)
Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK)
Gene: MAP3K14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14743216
Identification Methods	tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 947
+	Rn
		1144336 PABP1_RAT (1-636): 0: 579: 99.53		AKT3_RAT (272-696): 5.31e-132: 407: 19.15
+	Rn
		871332 PABP1_RAT (1-636): 0: 579: 99.53		AAPK1_RAT (374-909): 5.75e-123: 386: 17.30
+	Hs
		516351 PABP1_HUMAN (1-636): 0: 582: 100.00		KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46
+	Hs
		116962 PABP1_HUMAN (1-636): 0: 582: 100.00		SGK1_HUMAN (354-729): 7.08e-116: 363: 21.19
+	Hs
		568649 PABP4_HUMAN (1-635): 0: 534: 74.69		KAPCA_HUMAN (361-691): 1.53e-122: 378: 20.46
+	Hs
		516486 PABP1_HUMAN (1-636): 0: 582: 100.00		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Hs
		582451 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		M3K14_HUMAN (1-947): 0: 799: 100.00
+	Hs
		582149 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		KS6A3_HUMAN (319-656): 2.54e-97: 324: 20.46
+	Hs
		582261 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		STK4_HUMAN (405-650): 2.6e-99: 321: 30.80
+	Sc
		376640 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		STE11_YEAST (452-647): 9.17e-21: 100: 32.65
+	Hs
		582267 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		M3K1_HUMAN (370-643): 2.05e-24: 112: 30.52
+	Ce
		110182 Q19581_CAEEL (6-113): 4.07e-15: 80.7: 26.85		GCK1_CAEEL (401-647): 1.01e-21: 102: 33.99