HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: TNR6C (Q9HCJ0)
Trinucleotide repeat-containing gene 6C protein
Gene: TNRC6C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.977

Property	Details
Experiments	29395067, 21984184, 23340509, 21981923, 21063388, 20098421, 19716330, 20181956
Identification Methods	proximity labelling technology, affinity chromatography technology, x-ray crystallography, pull down, molecular sieving, nuclear magnetic resonance, anti tag coimmunoprecipitation, isothermal titration calorimetry
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	PABP~TNRC6-PABC_bdg, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 1936
+	Hs
		1031469 PABP4_HUMAN (1-635): 0: 534: 74.69		TNR6C_HUMAN (24-1936): 0: 762: 100.00
+	Hs
		516593 PABP1_HUMAN (1-636): 0: 582: 100.00		TNR6A_HUMAN (2-1933): 2.2e-125: 440: 35.43
+	Hs
		516746 PABP1_HUMAN (1-636): 0: 582: 100.00		TNR6B_HUMAN (18-1920): 9.22e-118: 415: 30.70
+	Hs
		516749 PABP1_HUMAN (1-636): 0: 582: 100.00		SRRM2_HUMAN (269-1785): 4.31e-20: 100: 8.50
+	Hs
		516595 PABP1_HUMAN (1-636): 0: 582: 100.00		KMT2C_HUMAN (1225-1780): 8.8e-16: 86.5: 10.80
+	Dm
		597064 PABP_DROME (2-448): 6.58e-63: 221: 25.21		GAWKY_DROME (650-1849): 7.88e-73: 271: 21.24
+	Hs
		1288650 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		SRRM2_HUMAN (269-1785): 4.31e-20: 100: 8.50
+	Hs
		582534 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		RRBP1_HUMAN (37-517): 3.13e-11: 71.1: 10.56