HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: G3BP2 (Q9UN86)
Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2)
Gene: G3BP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	29395067, 23279204, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010494 - cytoplasmic stress granule and 1 others more... GO:1990904 - ribonucleoprotein complex
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 482
+	Hs
		1031497 PABP4_HUMAN (1-635): 0: 534: 74.69		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		516494 PABP1_HUMAN (1-636): 0: 582: 100.00		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		1030211 PABP4_HUMAN (1-635): 0: 534: 74.69		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Hs
		516621 PABP1_HUMAN (1-636): 0: 582: 100.00		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Hs
		1031413 PABP4_HUMAN (1-635): 0: 534: 74.69		CELF1_HUMAN (323-419): 4.95e-15: 79.2: 18.63
+	Zm
		22429 A0A1D6I0G1_MAIZE (2-492): 3.86e-68: 236: 22.73		A0A1D6Q2L8_MAIZE (6-475): 6.16e-65: 218: 23.80
+	Hs
		582556 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		G3BP2_HUMAN (1-482): 5.94e-108: 330: 100.00
+	Hs
		680445 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		G3BP1_HUMAN (1-460): 6.81e-83: 265: 56.81
+	Sc
		376881 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		BRE5_YEAST (9-419): 2.98e-56: 197: 15.59
+	Hs
		1049508 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		SAFB2_HUMAN (141-482): 1.89e-41: 160: 14.69