HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: TNR6B (Q9UPQ9)
Trinucleotide repeat-containing gene 6B protein
Gene: TNRC6B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	21063388, 29395067, 21981923
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	PABP~TNRC6-PABC_bdg
Common GO terms	GO:0003723 - RNA binding GO:0005829 - cytosol GO:0031047 - regulatory ncRNA-mediated gene silencing GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 1833
+	Hs
		516593 PABP1_HUMAN (1-636): 0: 582: 100.00		TNR6A_HUMAN (2-1833): 0: 785: 35.34
+	Hs
		516700 PABP1_HUMAN (1-636): 0: 582: 100.00		TNR6C_HUMAN (34-1830): 0: 655: 34.21
+	Hs
		1031469 PABP4_HUMAN (1-635): 0: 534: 74.69		TNR6C_HUMAN (34-1830): 0: 655: 34.21
+	Dm
		597064 PABP_DROME (2-448): 6.58e-63: 221: 25.21		GAWKY_DROME (615-1735): 3.49e-145: 488: 21.36
+	Hs
		582534 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		RRBP1_HUMAN (6-689): 6.03e-33: 142: 10.09