HitPredict

Interactor 1: SIR4 (P11978)
Regulatory protein SIR4 (Silent information regulator 4)
Gene: SIR4

Interactor 2: KU80 (Q04437)
ATP-dependent DNA helicase II subunit 2 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku80) (High affinity DNA-binding factor subunit 2) (Yeast Ku80)
Gene: YKU80

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.722

Property	Details
Experiments	14551211, 26218225, 29290466, 21852961, 22654676
Identification Methods	two hybrid, pull down, x-ray crystallography, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003690 - double-stranded DNA binding GO:0006303 - double-strand break repair via nonhomologous end joining GO:0031509 - subtelomeric heterochromatin formation GO:0097695 - establishment of protein-containing complex localization to telomere
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1 1358 Sc			1 629
+	Sc
		516860 SIR4_YEAST (1-1358): 0: 2508: 100.00		KU70_YEAST (4-555): 7.12e-82: 271: 16.44