HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.95	1.00	0.975

Method score

Annotation score

Interaction score

0.95

1.00

0.975

Property	Details
Experiments	25416956, 21364740, 30301766, 32296183, 9545252, 15805117, 26030842, 31515488, unassigned1304, 15681588
Identification Methods	two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid array, cross-linking study, anti tag coimmunoprecipitation, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, association, physical association

Property

Details

Experiments

25416956, 21364740, 30301766, 32296183, 9545252, 15805117, 26030842, 31515488, unassigned1304, 15681588

Identification Methods

two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid array, cross-linking study, anti tag coimmunoprecipitation, two hybrid prey pooling approach, validated two hybrid

Interaction Type

direct interaction, association, physical association

Property	Details
Interacting Pfam domains	PCNA_C~PCNA_C, PCNA_C~PCNA_N, PCNA_N~PCNA_N
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0000701 - purine-specific mismatch base pair DNA N-glycosylase activity GO:0000781 - chromosome, telomeric region GO:0000785 - chromatin and 44 others more... GO:0001673 - male germ cell nucleus GO:0003682 - chromatin binding GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005652 - nuclear lamina GO:0005654 - nucleoplasm GO:0005657 - replication fork GO:0005813 - centrosome GO:0006272 - leading strand elongation GO:0006287 - base-excision repair, gap-filling GO:0006298 - mismatch repair GO:0007507 - heart development GO:0016604 - nuclear body GO:0019899 - enzyme binding GO:0019985 - translesion synthesis GO:0030331 - nuclear estrogen receptor binding GO:0030337 - DNA polymerase processivity factor activity GO:0030855 - epithelial cell differentiation GO:0030894 - replisome GO:0030971 - receptor tyrosine kinase binding GO:0031297 - replication fork processing GO:0032077 - positive regulation of deoxyribonuclease activity GO:0032139 - dinucleotide insertion or deletion binding GO:0032355 - response to estradiol GO:0032405 - MutLalpha complex binding GO:0034644 - cellular response to UV GO:0035035 - histone acetyltransferase binding GO:0043596 - nuclear replication fork GO:0043626 - PCNA complex GO:0044849 - estrous cycle GO:0044877 - protein-containing complex binding GO:0045739 - positive regulation of DNA repair GO:0045740 - positive regulation of DNA replication GO:0046686 - response to cadmium ion GO:0070062 - extracellular exosome GO:0070182 - DNA polymerase binding GO:0070301 - cellular response to hydrogen peroxide GO:0070557 - PCNA-p21 complex GO:0071466 - cellular response to xenobiotic stimulus GO:0071548 - response to dexamethasone GO:0097421 - liver regeneration GO:1900264 - positive regulation of DNA-directed DNA polymerase activity GO:1902065 - response to L-glutamate GO:1902990 - mitotic telomere maintenance via semi-conservative replication
Homologous interactions	15