HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	7908906, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 292
+	Hs
		517055 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CCND1_HUMAN (2-292): 1.65e-100: 298: 51.86
+	Hs
		517031 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CCNB1_HUMAN (10-285): 8.22e-89: 272: 23.02
+	Hs
		517044 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CCNA2_HUMAN (1-283): 1.9e-87: 269: 25.61
+	Hs
		517080 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CCND2_HUMAN (1-292): 1.54e-81: 249: 61.15
+	Hs
		331628 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CCNE2_HUMAN (13-243): 1.83e-18: 86.7: 27.47
+	Hs
		517059 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CCNE1_HUMAN (14-208): 1.34e-15: 78.2: 29.13
+	Zm
		1115069 PCNA_MAIZE (1-259): 2.34e-115: 333: 62.93		Q8S524_MAIZE (21-272): 2.71e-15: 77: 29.39