HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: MSH2 (P43246)
DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)
Gene: MSH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	12171929, 15225546
Identification Methods	affinity chromatography technology, far western blotting
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003682 - chromatin binding GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0006298 - mismatch repair
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 934
+	Hs
		517148 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		MSH6_HUMAN (7-855): 0: 787: 22.11
+	Sc
		550522 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		MSH2_YEAST (10-931): 0: 806: 39.53
+	Sp
		251607 PCNA_SCHPO (1-259): 1.09e-108: 316: 50.97		MSH6_SCHPO (7-882): 0: 770: 22.79
+	Hs
		517045 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		MSH3_HUMAN (6-861): 0: 721: 23.13
+	Sc
		550570 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		MSH6_YEAST (7-862): 0: 702: 22.62
+	Sc
		550518 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		MSH3_YEAST (6-855): 0: 622: 22.20