HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: CDK5 (Q00535)
Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit)
Gene: CDK5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33961781, 11254741, 9545286
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 292
+	Bt
		1114085 PCNA_BOVIN (1-261): 4.42e-126: 360: 99.23		CDK2_BOVIN (1-292): 7.85e-144: 407: 59.73
+	Hs
		517061 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CDK2_HUMAN (1-292): 2.7e-143: 406: 59.39
+	Bt
		970690 PCNA_BOVIN (1-261): 4.42e-126: 360: 99.23		CDK5_BOVIN (1-292): 9.13e-139: 394: 99.66
+	Mm
		572245 PCNA_MOUSE (1-261): 1.25e-125: 358: 96.94		CDK2_MOUSE (1-292): 7.36e-136: 389: 51.77
+	Hs
		414703 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CDK1_HUMAN (1-289): 1.13e-134: 384: 56.01
+	Hs
		517133 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CDK7_HUMAN (2-292): 2.63e-127: 367: 45.24