HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35563538, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 768
+	Mm
		572247 PCNA_MOUSE (1-261): 1.25e-125: 358: 96.94		CUL4A_MOUSE (5-768): 0: 796: 37.68
+	Hs
		517247 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		517248 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		517244 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		517245 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Dm
		572202 PCNA_DROME (1-259): 1.18e-122: 351: 71.04		Q9V9R2_DROME (30-768): 0: 612: 24.52
+	Hs
		517394 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Dm
		1196761 Q868I9_DROME (1-36): 3.11e-09: 53.1: 63.89		Q9V9R2_DROME (30-768): 0: 612: 24.52