HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: HLTF (Q14527)
Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)
Gene: HLTF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	28924044, 30696947, 32701997, 22904075, 26350214, 31973093, 18316726, 18719106
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 1009
+	Hs
		517468 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		SMRCD_HUMAN (193-1009): 1.61e-152: 480: 18.47
+	Mm
		572258 PCNA_MOUSE (1-261): 1.25e-125: 358: 96.94		SMCA5_MOUSE (284-928): 1.06e-148: 471: 16.01
+	Sc
		550532 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		RAD5_YEAST (82-1008): 1.05e-150: 479: 21.89
+	Sc
		550580 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		ULS1_YEAST (468-1009): 1.74e-129: 431: 26.89
+	Hs
		517262 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		SHPRH_HUMAN (758-970): 1.04e-18: 94.4: 29.41
+	At
		1324854 PCNA1_ARATH (1-261): 8.59e-119: 342: 64.75		SM3L2_ARATH (66-314): 2.63e-22: 105: 21.52
+	At
		1324855 PCNA2_ARATH (1-261): 1.41e-118: 341: 65.52		SM3L2_ARATH (66-314): 2.63e-22: 105: 21.52
+	Sc
		550533 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		RAD54_YEAST (823-989): 1.55e-20: 99.8: 35.93