HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: ATAD5 (Q96QE3)
ATPase family AAA domain-containing protein 5 (Chromosome fragility-associated gene 1 protein)
Gene: ATAD5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	26496610, 20147293
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	AAA~PCNA_C, AAA~PCNA_N
Common GO terms	GO:0005634 - nucleus GO:0045740 - positive regulation of DNA replication
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 1844
+	Hs
		517312 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		NIPBL_HUMAN (66-837): 6.64e-54: 211: 12.10
+	Hs
		517101 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		RFC1_HUMAN (433-1276): 4.59e-53: 207: 14.77
+	Hs
		517383 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		CTF18_HUMAN (998-1222): 2.17e-34: 146: 17.57
+	Ce
		137350 PCNA_CAEEL (1-260): 8.65e-107: 311: 47.89		Q18841_CAEEL (778-1293): 4.07e-39: 160: 16.35
+	Sc
		550563 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		CTF18_YEAST (1020-1501): 1.12e-36: 152: 16.03
+	Sc
		550542 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		RFC1_YEAST (711-1292): 1.4e-34: 146: 14.55
+	Hs
		517123 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		ATRX_HUMAN (88-1036): 2.62e-11: 71.5: 13.08