HitPredict

Interactor 1: A4 (P12023)
Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: App

Interactor 2: DAB2 (P98078)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Mitogen-responsive phosphoprotein)
Gene: DAB2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12826668
Identification Methods	x-ray crystallography
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	APP_amyloid~PID
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0046330 - positive regulation of JNK cascade GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 770 Mm			1 766
+	Hs
		394535 A4_HUMAN (19-770): 0: 987: 96.81		DAB2_HUMAN (1-766): 8.87e-80: 273: 81.76
+	Mm
		517715 A4_MOUSE (1-770): 0: 1018: 100.00		NUMB_MOUSE (26-678): 7.52e-45: 173: 13.19
+	Mm
		517618 A4_MOUSE (1-770): 0: 1018: 100.00		DAB1_MOUSE (11-617): 3.62e-37: 149: 24.35
+	Hs
		394340 A4_HUMAN (19-770): 0: 987: 96.81		NUMB_HUMAN (26-678): 6e-47: 179: 14.24
+	Hs
		394888 A4_HUMAN (19-770): 0: 987: 96.81		ARH_HUMAN (12-247): 8.44e-49: 176: 13.58
+	Hs
		395052 A4_HUMAN (19-770): 0: 987: 96.81		ANS1B_HUMAN (2-236): 1.85e-43: 172: 17.99
+	Hs
		957169 APLP2_HUMAN (3-769): 0: 870: 48.73		DAB2_HUMAN (1-766): 8.87e-80: 273: 81.76
+	Hs
		253522 A4_HUMAN (19-770): 0: 987: 96.81		CAPON_HUMAN (21-284): 6.11e-38: 150: 14.53
+	Hs
		269118 A4_HUMAN (19-770): 0: 987: 96.81		DAB1_HUMAN (11-617): 1.62e-37: 150: 23.57
+	Hs
		394059 A4_HUMAN (19-770): 0: 987: 96.81		MUC1_HUMAN (243-761): 5.4e-25: 113: 11.28
+	Hs
		269140 APLP2_HUMAN (3-769): 0: 870: 48.73		DAB1_HUMAN (11-617): 1.62e-37: 150: 23.57
+	Mm
		956226 APLP2_MOUSE (3-769): 0: 782: 45.43		DAB1_MOUSE (11-617): 3.62e-37: 149: 24.35
+	Hs
		849925 APLP1_HUMAN (11-207): 2.43e-69: 242: 42.93		DAB2_HUMAN (1-766): 8.87e-80: 273: 81.76
+	Hs
		269127 APLP1_HUMAN (11-207): 2.43e-69: 242: 42.93		DAB1_HUMAN (11-617): 1.62e-37: 150: 23.57
+	Mm
		956224 APLP1_MOUSE (11-207): 8.27e-70: 243: 41.92		DAB1_MOUSE (11-617): 3.62e-37: 149: 24.35
+	Hs
		253541 TFPI2_HUMAN (219-394): 7.4e-19: 88.5: 14.75		CAPON_HUMAN (21-284): 6.11e-38: 150: 14.53