HitPredict

Interactor 1: A4 (P12023)
Amyloid-beta precursor protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]
Gene: App

Interactor 2: APBA2 (P98084)
Amyloid-beta A4 precursor protein-binding family A member 2 (Adapter protein X11beta) (Neuron-specific X11L protein) (Neuronal Munc18-1-interacting protein 2) (Mint-2)
Gene: APBA2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 20925061, 11517249
Identification Methods anti bait coimmunoprecipitation, pull down
Interaction Type association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains APP_amyloid~PID
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0007626 - locomotory behavior
GO:0010468 - regulation of gene expression
GO:0043197 - dendritic spine
Homologous interactions 12

Homologous interactions

Color coding for hit scores

1 770
Mm

1 750
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Dm
+ Ce
+ Ce

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Last updated: 15 Jul 2024