Interactor 1: HARS1 (P12081)
Histidine--tRNA ligase, cytoplasmic (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS)
Gene: HARS1

Interactor 2: SYHM (P49590)
Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS)
Gene: HARS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.895

The method score is based on:

Property Details
Experiments 28514442, 33961781, 35235311, 34349018
Identification Methods affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HGTP_anticodon~HGTP_anticodon, HGTP_anticodon~tRNA-synt_His, tRNA-synt_His~tRNA-synt_His, WHEP-TRS~tRNA-synt_His
Common GO terms GO:0003723 - RNA binding
GO:0004821 - histidine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol
and 3 others

more...

Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 509
Hs

1 506
+ Hs
+ Hs
+ Sp
+ Tp
+ Sc
+ Sp
+ Cj
+ Sc
+ Ec
+ Hs
+ Hs
+ Sc
+ Hs

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Last updated: 15 Jul 2024