HitPredict

Interactor 1: TPR (P12270)
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)
Gene: TPR

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26831064, 34591612
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0015631 - tubulin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2363 Hs			1 1863
+	Hs
		749227 CENPF_HUMAN (270-2309): 1.3e-43: 178: 10.34		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		724691 MYH9_HUMAN (1404-2309): 4.5e-28: 127: 9.29		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		725099 MYH10_HUMAN (2-563): 2.37e-21: 104: 15.02		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749506 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		551628 DESP_HUMAN (688-1584): 5.95e-11: 70.5: 18.36		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		148473 CTRO_HUMAN (1173-1646): 8.14e-09: 63.5: 22.34		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Xl
		936125 P70012_XENLA (1-1457): 6.6e-51: 202: 10.76		Q90X96_XENLA (1-846): 8.6e-74: 275: 22.02
+	Hs
		522639 MYH7_HUMAN (1098-2165): 1.22e-38: 161: 10.38		TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54
+	Hs
		528393 MYH6_HUMAN (1310-2320): 5.95e-32: 139: 10.02		TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54
+	Mm
		93758 E9QAH1_MOUSE (970-2287): 7.37e-29: 129: 9.01		TRI27_MOUSE (13-390): 9.45e-70: 246: 11.74
+	Xl
		936124 P70012_XENLA (1-1457): 6.6e-51: 202: 10.76		Q90X95_XENLA (9-373): 1.07e-26: 120: 12.75
+	Hs
		149258 CTRO_HUMAN (1173-1646): 8.14e-09: 63.5: 22.34		TRIM4_HUMAN (15-377): 1.5e-62: 225: 11.52
+	Hs
		1019325 CNTRL_HUMAN (2-538): 3.64e-12: 74.7: 12.68		TRI26_HUMAN (12-287): 2.53e-51: 193: 14.53
+	Hs
		725005 MYH9_HUMAN (1404-2309): 4.5e-28: 127: 9.29		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		725238 MYH10_HUMAN (2-563): 2.37e-21: 104: 15.02		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		1061218 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		BARD1_HUMAN (13-366): 4.46e-32: 137: 11.98
+	Mm
		1093546 MYH9_MOUSE (1370-2342): 2.48e-31: 137: 10.58		TRI72_MOUSE (18-91): 9.41e-12: 71.5: 30.26