HitPredict

Interactor 1: TPR (P12270)
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)
Gene: TPR

Interactor 2: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	29568061, unassigned1655
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2363 Hs			1 346
+	Hs
		414704 TPR_HUMAN (1-2351): 7.93e-175: 597: 100.00		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		528401 MYH8_HUMAN (1310-2333): 3.23e-33: 144: 10.47		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		522604 MYH7_HUMAN (1098-2165): 1.22e-38: 161: 10.38		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		522542 MYH1_HUMAN (1204-2274): 3.68e-38: 160: 10.14		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		414820 CENPF_HUMAN (270-2309): 1.3e-43: 178: 10.34		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		960129 MYH13_HUMAN (1098-2165): 8.48e-35: 149: 10.63		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		625176 MYH9_HUMAN (1404-2309): 4.5e-28: 127: 9.29		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		960128 MYH2_HUMAN (1310-2333): 1.22e-33: 145: 10.75		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		528405 MYH8_HUMAN (1310-2333): 3.23e-33: 144: 10.47		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		724717 MYH9_HUMAN (1404-2309): 4.5e-28: 127: 9.29		CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00
+	Hs
		528368 MYH6_HUMAN (1310-2320): 5.95e-32: 139: 10.02		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		625177 MYH10_HUMAN (2-563): 2.37e-21: 104: 15.02		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		725114 MYH10_HUMAN (2-563): 2.37e-21: 104: 15.02		CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00
+	Hs
		502908 MYH3_HUMAN (20-755): 3.98e-18: 94.3: 13.34		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		625530 MY18A_HUMAN (672-1418): 3.18e-12: 74.7: 20.60		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		625440 NUMA1_HUMAN (1475-2060): 2.53e-11: 72: 10.08		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		841254 CNTRL_HUMAN (2-538): 3.64e-12: 74.7: 12.68		CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00
+	Sc
		339675 MLP2_YEAST (346-1680): 1.27e-26: 122: 12.89		CDK1_YEAST (11-297): 3.02e-125: 362: 42.52
+	Sc
		339800 MLP1_YEAST (803-2121): 2.34e-26: 121: 8.26		CDK1_YEAST (11-297): 3.02e-125: 362: 42.52
+	Hs
		414713 DESP_HUMAN (688-1584): 5.95e-11: 70.5: 18.36		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00