Interactor 1: PTHR (P12272)
Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]
Gene: PTHLH

Interactor 2: PTH1R (Q03431)
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
Gene: PTH1R

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 0.90 0.777

The method score is based on:

Property Details
Experiments 9108031, 19674967
Identification Methods pull down, x-ray crystallography, bio-layer interferometry
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_2~Parathyroid, HRM~Parathyroid
Common GO terms GO:0001501 - skeletal system development
GO:0002076 - osteoblast development
GO:0005737 - cytoplasm
GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
and 2 others

more...

Homologous interactions 0

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Last updated: 15 Jul 2024