HitPredict

Interactor 1: A1Z6Z9 (A1Z6Z9)
Dilute class unconventional myosin, isoform A
Gene: didum

Interactor 2: MLC2 (P54357)
Myosin-2 essential light chain (Myosin II essential light chain) (Non-muscle myosin essential light chain)
Gene: Mlc-c

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	16917818, 15980429, 18585038, 14605208
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	EF-hand_6~IQ, EF-hand_7~IQ, EF-hand_6~Myosin_head, EF-hand_7~Myosin_head
Common GO terms	GO:0030048 - actin filament-based movement GO:0031475 - myosin V complex
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1792 Dm			1 147
+	Dm
		51921 A1Z6Z9_DROME (1-1792): 0: 1209: 100.00		CALM_DROME (3-146): 1.12e-46: 149: 43.45
+	Hs
		484218 MYO5B_HUMAN (6-1792): 0: 1100: 37.86		CALM3_HUMAN (3-146): 3.02e-47: 151: 43.45
+	Hs
		484206 MYO5C_HUMAN (3-1790): 0: 995: 35.16		CALM3_HUMAN (3-146): 3.02e-47: 151: 43.45
+	Dm
		906697 MYO7A_DROME (14-949): 0: 905: 33.30		CALM_DROME (3-146): 1.12e-46: 149: 43.45
+	Dm
		870146 MYO7A_DROME (14-949): 0: 905: 33.30		MLC2_DROME (1-147): 9.93e-45: 144: 100.00
+	Sc
		420253 MYO4_YEAST (6-1055): 0: 875: 36.97		CALM_YEAST (2-146): 1.14e-45: 147: 37.42
+	Hs
		484202 MYO10_HUMAN (5-1021): 0: 857: 30.87		CALM3_HUMAN (3-146): 3.02e-47: 151: 43.45
+	Hs
		648611 MYO10_HUMAN (5-1021): 0: 857: 30.87		CALL3_HUMAN (3-146): 5.6e-44: 143: 41.38
+	Sp
		251969 MYO51_SCHPO (4-1116): 0: 865: 32.00		CALM_SCHPO (72-144): 1.05e-10: 57.9: 27.03
+	Sp
		293469 MYO52_SCHPO (7-990): 0: 632: 38.15		CALM_SCHPO (72-144): 1.05e-10: 57.9: 27.03
+	Hs
		538642 MYH9_HUMAN (764-1454): 1.17e-28: 128: 11.66		MYL6B_HUMAN (3-146): 1.59e-47: 154: 53.38
+	Hs
		724737 MYH9_HUMAN (764-1454): 1.17e-28: 128: 11.66		MYL6_HUMAN (1-147): 1.81e-45: 147: 53.64
+	Hs
		648467 MYH9_HUMAN (764-1454): 1.17e-28: 128: 11.66		CALL3_HUMAN (3-146): 5.6e-44: 143: 41.38
+	Sc
		420223 MYO2_YEAST (996-1768): 3.74e-25: 116: 12.98		CALM_YEAST (2-146): 1.14e-45: 147: 37.42
+	Hs
		441665 MYH9_HUMAN (764-1454): 1.17e-28: 128: 11.66		MYL3_HUMAN (4-146): 8.71e-40: 134: 48.99