HitPredict

Interactor 1: FCGR1 (P12314)
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
Gene: FCGR1A

Interactor 2: FCAR (P24071)
Immunoglobulin alpha Fc receptor (IgA Fc receptor) (CD antigen CD89)
Gene: FCAR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	8530370, 16517729
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ig~ig, Ig_2~ig, Ig_3~ig
Common GO terms	GO:0005886 - plasma membrane GO:0006955 - immune response
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 287
+	Hs
		798136 KI3L1_HUMAN (5-351): 7.29e-53: 183: 18.02		KI2L1_HUMAN (1-267): 2.03e-72: 228: 26.55
+	Hs
		519341 FCGR1_HUMAN (1-374): 1.3e-99: 301: 100.00		VSTM1_HUMAN (124-252): 1.25e-13: 70.4: 23.19
+	Hs
		798235 KI3S1_HUMAN (5-322): 2.76e-57: 193: 18.80		KI3L1_HUMAN (16-267): 5.1e-36: 135: 24.72
+	Hs
		798168 KI3S1_HUMAN (5-322): 2.76e-57: 193: 18.80		KI2L2_HUMAN (121-284): 8.78e-27: 108: 24.85
+	Hs
		798163 KI3L1_HUMAN (5-351): 7.29e-53: 183: 18.02		KI2L2_HUMAN (121-284): 8.78e-27: 108: 24.85
+	Hs
		519370 FCG2A_HUMAN (103-290): 5.25e-31: 121: 15.96		FCG2C_HUMAN (7-276): 1.53e-47: 162: 18.25
+	Hs
		798230 KI3L1_HUMAN (5-351): 7.29e-53: 183: 18.02		KI2S2_HUMAN (120-284): 7.06e-23: 97.5: 25.29
+	Hs
		47501 A0A8I5QEB2_HUMAN (10-351): 2.5e-52: 180: 18.95		KI2S5_HUMAN (123-284): 1.09e-21: 94: 24.55
+	Hs
		519369 FCG2A_HUMAN (103-290): 5.25e-31: 121: 15.96		FCG2B_HUMAN (7-222): 2.99e-43: 151: 17.73
+	Hs
		507951 FGFR1_HUMAN (1-370): 2.07e-57: 201: 15.86		PGBM_HUMAN (29-237): 3.42e-09: 59.7: 13.70
+	Hs
		442917 FCG3A_HUMAN (99-322): 1.23e-33: 127: 15.79		KI2L4_HUMAN (121-284): 1.4e-25: 105: 24.39
+	Dm
		219801 O44924_DROME (9-105): 1.06e-16: 84: 18.27		O44924_DROME (18-235): 4.49e-37: 141: 14.35
+	Ce
		103933 SAX3_CAEEL (20-283): 9.26e-36: 140: 14.38		SAX3_CAEEL (27-212): 4.68e-17: 83.2: 9.66
+	Hs
		1378225 ROBO1_HUMAN (186-373): 2.25e-23: 104: 13.58		ROBO1_HUMAN (120-273): 1.05e-20: 94: 12.65
+	Hs
		1336275 ROBO1_HUMAN (186-373): 2.25e-23: 104: 13.58		ROBO2_HUMAN (120-273): 2.06e-20: 93.2: 12.65
+	Hs
		532364 CEAM1_HUMAN (18-262): 2.2e-18: 88.6: 21.40		CEAM6_HUMAN (74-284): 2e-18: 85.6: 14.55
+	Hs
		1336269 ROBO2_HUMAN (20-105): 1.22e-13: 74.4: 17.02		ROBO2_HUMAN (120-273): 2.06e-20: 93.2: 12.65