HitPredict

Interactor 1: FCG2A (P12318)
Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
Gene: FCGR2A

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	9268059, 11141335, 15136586, 7487883
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type	direct interaction, physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0032760 - positive regulation of tumor necrosis factor production
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 635
+	Hs
		442909 FCG3A_HUMAN (16-255): 1.34e-61: 198: 43.03		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		519406 FCERA_HUMAN (20-247): 4.5e-59: 191: 32.02		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		590606 CD22_HUMAN (31-309): 1.51e-30: 123: 16.61		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		796632 FCRL3_HUMAN (22-311): 1.52e-27: 114: 17.65		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		519328 FCGR1_HUMAN (30-277): 9.95e-25: 104: 16.54		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Mm
		722897 CD22_MOUSE (28-290): 2.28e-25: 108: 13.25		KSYK_MOUSE (1-635): 0: 567: 92.13
+	Hs
		796482 FCRL3_HUMAN (22-311): 1.52e-27: 114: 17.65		ZAP70_HUMAN (6-635): 0: 535: 53.57
+	Hs
		522812 FCG2C_HUMAN (1-317): 2.11e-73: 230: 85.17		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		412048 FCG2C_HUMAN (1-317): 2.11e-73: 230: 85.17		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		507819 NCAM1_HUMAN (126-316): 4.02e-20: 92.9: 13.37		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		530151 NCAM1_HUMAN (126-316): 4.02e-20: 92.9: 13.37		EPHA3_HUMAN (174-632): 2.58e-114: 366: 24.89
+	Hs
		411560 FCG3A_HUMAN (16-255): 1.34e-61: 198: 43.03		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Hs
		519400 FCERA_HUMAN (20-247): 4.5e-59: 191: 32.02		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Dm
		219802 O44924_DROME (3-306): 2.92e-48: 175: 12.77		ABL_DROME (4-374): 5.52e-57: 210: 14.54
+	Hs
		523211 TUTLB_HUMAN (28-309): 3.52e-25: 107: 14.84		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		433507 TUTLB_HUMAN (28-309): 3.52e-25: 107: 14.84		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Hs
		442771 FCGR1_HUMAN (30-277): 9.95e-25: 104: 16.54		HCK_HUMAN (4-371): 1.18e-67: 231: 14.65
+	Hs
		337853 NCAM1_HUMAN (126-316): 4.02e-20: 92.9: 13.37		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		789014 TUTLB_HUMAN (28-309): 3.52e-25: 107: 14.84		TEC_HUMAN (4-379): 4.35e-48: 180: 12.71
+	Mm
		435878 FCGR1_MOUSE (7-311): 3.47e-26: 108: 17.28		HCK_MOUSE (15-176): 1.32e-38: 151: 23.37