HitPredict

Interactor 1: FCERA (P12319)
High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)
Gene: FCER1A

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9103201
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043303 - mast cell degranulation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 257 Hs			1 635
+	Hs
		442909 FCG3A_HUMAN (18-241): 3.92e-45: 153: 36.71		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		519372 FCG2A_HUMAN (19-204): 2.17e-44: 153: 35.48		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		590606 CD22_HUMAN (19-251): 8.05e-29: 116: 18.85		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		796632 FCRL3_HUMAN (23-242): 1.23e-21: 95.6: 17.92		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		519328 FCGR1_HUMAN (32-236): 3.38e-21: 93.2: 20.55		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Hs
		796482 FCRL3_HUMAN (23-242): 1.23e-21: 95.6: 17.92		ZAP70_HUMAN (6-635): 0: 535: 53.57
+	Hs
		519400 FCERA_HUMAN (1-257): 4.03e-70: 218: 100.00		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		522811 FCG2B_HUMAN (2-247): 4.45e-50: 168: 33.60		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		522812 FCG2C_HUMAN (2-241): 4.57e-49: 166: 34.03		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		412047 FCG2B_HUMAN (2-247): 4.45e-50: 168: 33.60		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		412048 FCG2C_HUMAN (2-241): 4.57e-49: 166: 34.03		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		411560 FCG3A_HUMAN (18-241): 3.92e-45: 153: 36.71		LCK_HUMAN (5-201): 3.03e-71: 240: 23.29
+	Dm
		219802 O44924_DROME (2-213): 9.93e-36: 136: 15.23		ABL_DROME (4-374): 5.52e-57: 210: 14.54
+	Hs
		523211 TUTLB_HUMAN (1-215): 3.83e-24: 103: 13.69		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		433507 TUTLB_HUMAN (1-215): 3.83e-24: 103: 13.69		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Dm
		337644 LAR_DROME (30-218): 2.88e-30: 120: 18.27		ABL_DROME (4-374): 5.52e-57: 210: 14.54
+	Hs
		442771 FCGR1_HUMAN (32-236): 3.38e-21: 93.2: 20.55		HCK_HUMAN (4-371): 1.18e-67: 231: 14.65
+	Mm
		56907 PTPRF_MOUSE (2-141): 1.68e-12: 69: 14.10		FYN_MOUSE (4-201): 6.63e-69: 235: 22.03
+	Hs
		789014 TUTLB_HUMAN (1-215): 3.83e-24: 103: 13.69		TEC_HUMAN (4-379): 4.35e-48: 180: 12.71
+	Mm
		435878 FCGR1_MOUSE (32-228): 1.2e-23: 100: 21.91		HCK_MOUSE (15-176): 1.32e-38: 151: 23.37